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Domains

 
 
 

Fermentation and Bioprocessing (FBP)

Biopharmaceutical are protein-based (including antibodies), nucleic acids (DNA, RNA or antisense oligonucleotides) used for therapeutic or in vivo diagnostic purpose and are produced from genetically altered microorganisms or may come from blood or blood plasma products (usually referred to as biologics). The first such substance approved for therapeutic use was biosynthetic human insulin made via recombinant DNA technology. This domain deals with the production of therapeutic proteins on using different expression systems as well as high cell density fermentation including media selection, preparation and sterilization, fermenter functional design, sterilization in place and sterilization process validation, fermenter inoculation and maintenance of different fermentation parameters, scale up of fermentation process, fermenter harvest and cleaning process validation. For animal cell culture, media preparation and sterilization by filtration, sub-culturing, suspension culture and monitoring, of bioreactor cultures. In downstream processing, familiarization with chromatography equipment, column packing methods, column equilibration, and operation of tangential flow filtration as well as its cleaning and sanitation, dead end filtration will also be part of the curriculum. In addition, regulatory requirements of different countries and cGMP requirements for the production area of biopharmaceuticals will also be covered.

Application & future prospects

Pharmaceutical proteins produced via fermentation in transgenic microbes or mammalian cell culture systems provide economical systems for production of therapeutic proteins. Fermentation systems can be scaled up to produce quantities of pharmaceuticals that are difficult or impossible to produce via traditional methods. In addition rapid growth rate and high productivity, higher product content per unit of cells, the process occupy little land area, production is independent of seasonal variations and climatic conditions has added advantages to the fermentation process. Some of the Biopharma products are produced commercially through fermentation routes are - Human insulin, Streptokinase, Erythropoietin, Hepatitis B Vaccine, Human growth hormone, Interleukin, GCSF, GMCSF, Alfa-Interferon, Gamma Interferon etc. In the fastest growing biotech industry, biopharmaceuticals consist of about 62% of the $3 billion generated in financial year 2009-10. According to the 9th Biospectrum - ABLE Biotech Industry Survey 2011, the industry has grown by 21.5%, slightly less than $4 billion in financial year 2010-2011. Biopharma industries include Biocon, Serum Institute of India, Panacea Biotech, Reliance Life Sciences, Shantha Biotechniques, Indian Immunologicals, Bharat Biotech, Cadila Health Care, Intervet India, Intas Biopharma, Eli Lilly, Hafkine Biopharma, Glaxo Smith Kline, Novo Nordisk, etc.

Institution/s offering the course

Sl. No. Name and address of the Institution Contact Person / Details Code
1 St. Aloysius College
P.B No. 720, Light House Hill Road
Mangaluru - 575 003.
Dr. Jiji George
7760231210
SAC
2 University of Gulbarga
Jnana Ganga
Kalaburagi – 585106.
Dr. M.B. Sulochana
9449618676
084722 63290
GU
3 B.V.Bhoomaraddi College of Engineering and Technology
Vidyanagar
Hubballi – 580031.
Prof. Laxmikant R. Patil
9448232734
0836 2378290

Dr. Shivalingasarj Desai
9886172994
0836 2378290
BVBCET
4 Shri Dharmasthala Manjunatheshwara College
Ujire, Dakshina Kannada – 574240.
Prarthana J
9844186023
08256 236221

Dr. Manoj Godbole
9448943404
08256 236221
SDMU